The goal of the Limb Loss & Preservation Registry (LLPR) is to generate knowledge about which advances, and treatments impact the care of individuals with limb loss and limb difference. Consistent with quality registries that focus on other health populations, the LLPR will collect universal data elements and link hospital, provider, and patient-reported outcomes over time. The registry will strive to alleviate significant data gaps, increase access to care and improve care models related to prosthetics and limb preservation in the U.S.